7-Keto DHEA

7-Keto DHEA is a metabolite of DHEA (dehydroepiandrosterone), which is produced naturally in the body. While DHEA serves as a precursor to male and female sex hormones (androgens and estrogens), 7-Keto DHEA has a different profile and doesn't convert to these hormones. This distinction makes 7-Keto DHEA an interesting compound for those looking to harness its benefits without impacting their hormone levels.

History

7-Keto DHEA was discovered in the 1950s but only gained mainstream attention in recent decades as a supplement for anti-aging, weight loss, and muscle-building. Given its non-hormonal nature, it has become a preferred option for those wary of the hormonal side effects associated with DHEA supplementation.

Mechanism of Action

7-Keto DHEA does not convert into testosterone or estrogen, thereby offering a safer profile for individuals who want to avoid altering these hormone levels. It has anabolic properties, meaning it helps in the growth of muscle tissue and bone. It is also believed to accelerate metabolism and aid in fat loss by enhancing thermogenic enzyme activity.

FDA Indications

There are no FDA-approved indications for 7-Keto DHEA.

Off-Label Indications

Anabolic Benefits: 7-Keto DHEA enhances protein synthesis and helps in muscle building. However, clinical trials to corroborate this claim are limited.
Improved Insulin Sensitivity: Some studies suggest that 7-Keto DHEA could improve insulin sensitivity, although more research is needed in this area.
Hair Loss Prevention: There are anecdotal claims and limited studies that suggest 7-Keto DHEA may help in preventing hair loss, but this is yet to be confirmed in large-scale trials.

Side Effects

The side effects of 7-Keto DHEA are generally mild and may include nausea, dizziness, and skin irritation.

Drug Interactions

7-Keto DHEA may interact with medications like anticoagulants (increase risk of bleeding) and drugs affecting thyroid hormones (require dose adjustment due to its effect on metabolic rate and thermogenesis). Always discuss any new supplement regimen with your healthcare provider.

Dosing

The standard dosing ranges from 100-200mg per day, often divided into two doses.

Clinical Evidence

Although definitive large-scale clinical trials are lacking, smaller studies and anecdotal evidence suggest potential benefits in body composition and metabolic health.

Contraindications

Those with a history of hormone-sensitive cancers should avoid 7-Keto DHEA, although it does not convert to estrogen or testosterone itself.

References

Unfortunately, there is no FDA label for 7-Keto DHEA.